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Food Business Review | Monday, January 27, 2025
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Bifizen, a probiotic with four strains, shows promise in managing subthreshold depression, improving mood, reducing inflammation, and supporting overall mental and metabolic health.
FREMONT CA,: Emerging research suggests that Bifizen, a probiotic developed by Probiotical, offers a novel approach to managing subthreshold depression (sD), a condition characterized by mild but persistent depressive symptoms. This probiotic formulation combines four specific strains: Lactiplantibacillus plantarum LP01, Lacticaseibacillus rhamnosus LR06, Limosilactobacillus fermentum LF16, and Bifidobacterium longum 04. These strains work synergistically to promote a balanced gut microbiota, potentially influencing mood regulation through the gut-brain axis.
Recent studies have shown that individuals experiencing sD can benefit from Bifizen through notable improvements in depressive symptoms, including mood, anxiety, and stress levels. The product’s effects were demonstrated in a randomized, placebo-controlled clinical trial, which measured psychological symptoms and biomarkers like inflammation and oxidative stress. After 12 weeks of probiotic supplementation, participants in the probiotic group reported significant reductions in depressive symptoms compared to the placebo group. These results were also reflected in biological markers, including lower cortisol awakening response (CAR), reduced inflammation markers (hs-CRP), and improved antioxidant levels (GSH), all of which are associated with better mood and emotional regulation.
The study also explored metabolic improvements, with participants experiencing better glycemic control, particularly those with elevated glucose levels at baseline. This aspect of the research is significant as it links probiotics not just to mood improvement but for better metabolic health, which is often compromised in individuals with mental health issues.
Bifizen has been designed to support mental health in those with sD and to improve overall well-being. Its formulation is based on scientific research examining connection between gut health and mental health, emphasizing the importance of a balanced microbiome in emotional and psychological stability. Studies show that alterations in gut microbiota compositions, such as a reduction in beneficial bacteria, can exacerbate conditions like depression and anxiety. The probiotic strains in Bifizen counteract this imbalance, offering a safer, non-invasive alternative to traditional treatments.
The research also underlines the potential of probiotics in women, who are more likely to experience mood disorders. The positive outcomes in these trials suggest that Bifizen could be a beneficial addition to wellness programs, especially for those seeking non-pharmacological treatments. Probiotical’s product has already shown success in multiple studies since its development in 2016, with notable improvements in mood and behavior that last even after supplementation ends.
Given these promising findings, Bifizen stands out as an accessible, cost-effective solution for individuals dealing with subthreshold depression. It provides an option for those who may not meet the criteria for major depressive disorder but still suffer from depressive symptoms that impact their quality of life. Its formulation is allergen-free and available in hydrosoluble powder and capsule forms, making it easy for different populations to incorporate into their daily routines.
The continued development and research into Bifizen by Probiotical reflect the growing recognition of the importance of gut health in overall mental well-being. With further trials and studies on its long-term effects, probiotics like Bifizen could become an integral part of personalized, holistic health solutions aimed at improving both mental and physical health.
The findings from clinical trials provide substantial evidence that probiotics like Bifizen can offer significant mental health benefits. Its ability to address psychological and physiological symptoms marks a new frontier in the treatment of mood disorders, providing a safe, effective adjunct to conventional treatments. As more people seek alternatives to traditional mental health therapies, Bifizen could play a critical role in enhancing quality of life and supporting long-term well-being.