For most nutraceutical supplements, the journey from factory to pharmacy shelf is an unseen test of survival. Temperature shifts, transport time and interactions between active compounds quietly erode a product’s strength long before a customer opens the bottle. Vitamin C is the clearest example. Its molecular structure is so sensitive that even mild heat can destabilise it if the finished product does not respect the physicochemical properties. Yet under European food regulations governing the supplements, producers are not required to demonstrate that their ingredients remain active throughout a product’s lifespan. That gap between what labels promise and what consumers actually receive is what pushed John Kottaris to establish Pharmacros, a company that applies pharmaceutical-grade controls to nutritional supplements. It all began when Kottaris turned to collagen during recovery from an injury. The more he researched, the clearer it became that food regulations ensured hygiene and basic compliance. But they did not require stating how long the actives stayed viable or whether the formulations delivered the benefits they claimed. The issue wasn’t the ingredient itself. It was the absence of a system that required transparency to verify performance. “I realised if a supplement is meant to help people, it must behave like a scientific formulation that performs consistently from the first dose to the last. Anything short of that breaks consumer trust,” says Kottaris, founder and CEO. For Swiss-based Pharmacros, that principle defines every decision that follows. It works solely with EUapproved branded raw materials supported by clinical studies. Every batch is retested in-house against its certificate of analysis before formulation begins, because it believes that ingredients cannot be trusted unless they are traceable and scientifically supported. Stability is treated with the same rigour because it directly affects the consumer experience. Temperature shifts and interactions between active compounds are the primary reasons supplements lose strength. Pharmacros produces its liquid formulations at controlled room temperatures below 21 degrees Celsius. These conditions enable up to 11 combined, sensitive ingredients to remain stable together, allowing the final product to maintain a fully homogenised profile batch to batch. Ensuring that reliability led to one of the company’s most decisive steps. In 2020, Pharmacros shifted manufacturing to an ANSM-approved pharmaceutical GMP facility in Montélimar, France—a site authorised to produce liquid medicines. This move provided the level of uniformity physicians expect when recommending a product and ensured that it always behaves exactly as formulated, regardless of its travel route or storage duration.